Abstract
CD28 Superagonist Shock and Blockage of Motogenic T Cell Cascade.
Highlights
T cell motility is arrested by T cell receptor (TCR) recognition of cognate peptide-MHC complexes on antigen-presenting cells [1]
Ligation of CD28 and TCR collaborate to block a distinct protease-controlled step in the motogenic T cell cascade directed by the large transmembrane receptor low density lipoprotein receptor-related protein 1 (LRP1) and its high molecular weight ligand thrombospondin-1 (TSP-1) [2,3,4,5,6,7,8,9]
Encounter of the TCR and CD28 with cognate pMHC complexes and B7 on antigen-presenting cells seems to block a protease of a molecular cascade regulating T cell motility and integrin-dependent contacts
Summary
T cell motility is arrested by T cell receptor (TCR) recognition of cognate peptide-MHC (pMHC) complexes on antigen-presenting cells [1]. Ligation of CD28 and TCR collaborate to block a distinct protease-controlled step in the motogenic T cell cascade directed by the large transmembrane receptor low density lipoprotein receptor-related protein 1 (LRP1) and its high molecular weight ligand thrombospondin-1 (TSP-1) [2,3,4,5,6,7,8,9]. LRP1 and TSP-1 have a high turnover, their expression depends on sensing of components of the extracellular matrix (ECM) and other cells and they promote motility in response to ligation of integrin and chemokine receptors.
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