Abstract
CD26 antigen and HIV fusion?
Highlights
(1989)] showed that log[total IgE], adjusted for age, sex, and specific lgE-mediated skin test reactivity, was a significant predictor of asthma (P < 0.0001)
Studies of cell fusion mediated by recombinant CD4 and human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein indicate that this species restriction is unidirectional: CD4 must be present on a human cell type, whereas env functions comparably when expressed on human or nonhuman cells [2]
The fusion defect in CD4expressing nonhuman cells can be overcome by forming stable [5] or transient [6, 7] hybrids with human cells. These findings suggest the essential involvement of a human-specific accessory component in the CD4+ cell rather than the presence of a fusion inhibitor in the nonhuman cells or an inherent fusion incompatibility between human and nonhuman cell types
Summary
(1989)] showed that log[total IgE], adjusted for age, sex, and specific lgE-mediated skin test reactivity, was a significant predictor of asthma (P < 0.0001). We observed extensive cell fusion when HeLa cells co-expressing vacciniaencoded CD4 and CD26 were mixed with cells expressing vaccinia-encoded env (IIIB) (Fig. IC, top panel).
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