Abstract
Introduction: Early detection of colorectal cancer (CRC) is the key to reduce its related morbidity and mortality. Methods: One hundred CRC patients were included in this study, they were admitted at Mansoura Gastroenterology Center, Mansoura University and diagnosis was confirmed by pathology.100 apparently healthy individuals were served as the control group.CD24 (P170 C/T) and CD24 (P-534 A/C) single nucleotide polymorphisms (SNPs) were analyzed using polymerase chain reaction–restriction fragment length polymorphism (PCR/RFLP). Results: Regarding CD24 P170 C/T SNP, no statistically significant association was found between genotypes, alleles and risk of CRC. While, P-534 A/C; AC, CC, AC+CC genotypes and C allele showed significantly higher frequency in cases when compared to controls. CC and TC haplotypes were significantly associated with risk of CRC when compared to control group. Multivariate logistic regression analysis revealed that higher CEA and P-534 A/C (AC+CC) were considered as independent predictors of higher CRC stages. Conclusion: The current study observed an association between CD24 P-543 A/C SNP and the risk of developing CRC in Egyptian subjects.
Highlights
Detection of colorectal cancer (CRC) is the key to reduce its related morbidity and mortality
One hundred CRC patients were included in this study, they were admitted at Mansoura Gastroenterology Center, Mansoura University and diagnosis was confirmed by pathology.100 apparently healthy individuals were served as the control group.CD24 (P170 C/T) and CD24 (P-534 A/C) single nucleotide polymorphisms (SNPs) were analyzed using polymerase chain reaction–restriction fragment length polymorphism (PCR/RFLP)
Regarding CD24 P170 C/T SNP, no statistically significant association was found between genotypes, alleles and risk of CRC
Summary
Detection of colorectal cancer (CRC) is the key to reduce its related morbidity and mortality. CC and TC haplotypes were significantly associated with risk of CRC when compared to control group. Colorectal cancer (CRC) is the third most common cancer in the world and is characterized by its high lethality and morbidity Siegel et al (2020). It is one of the major leading causes of death in both males and females as it was responsible for 861,000 deaths worldwide in 2018 Bray et al (2018). It is a very heterogeneous disease that is caused by the interaction of genetic and environmental factors It develops through a gradual accumulation of genetic and epigenetic changes leading to the transformation of normal colonic mucosa into an invasive cancer Binefa et al (2014). The known risk factors for CRC include; a diet low in fruit and vegetables, excessive intake of red meat and saturated fat, alcohol intake, a sedentary lifestyle, smoking and obesity Gonzalez and Riboli (2010)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
