Abstract
Large conductance voltage- and Ca2+-activated K+ channels (BK channels) are formed by Slo1 subunits as a homotetramer. Besides Ca2+, other divalent cations, such as Cd2+, also activate BK channels. At high concentration (100 μM), Cd2+ also inhibits BK macroscopic currents by ∼30%. However, we found that if the inside-out patch containing BK channels was treated with solution containing 10 mM DTT for 5 minutes 100 μM Cd2+ completely inhibited both the inward and outward currents at various voltages.
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