Abstract
INTRODUCTION: NKT cells are innate lymphocytes known for their regulation of immune responses in cancer, autoimmunity, and microbial infection. Here, we present the novel finding that NKT cells are key regulators of cutaneous wound repair. Using an in vivo mouse model of cutaneous injury in conjunction with antibodies that block NKT cell activation, we show that NKT cells critically regulate the wound inflammatory milieu and the overall kinetics of wound closure.
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