Abstract
The X-linked hyper-IgM syndrome results from mutations in the CD154 gene. The contact of CD154 with its ligand, CD40, underlies a wide variety of immunoregulatory cellular dialogues. This article provides an overview of the physiology of CD40-154 interactions and presents a detailed description of the clinical and immunologic features of more than 100 reported cases of XHIM. Aspects of the genetics, diagnosis, and treatment of XHIM and the clinical and immunologic features of the autosomal recessive forms of hyper-IgM syndrome in comparison with XHIM are also discussed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
