Abstract
Gastric cancer (GC) is one of the most common malignancies worldwide. The expression of CD147 protein is associated with GC. However, the clinical role of CD147 in GC has not been investigated extensively. Hence, we focused on studying the association between the expression of CD147 and clinicopathological features of GC patients in this study. Firstly, sixteen publications (1752 cases and 391 controls) and one from our own original research (143 cases) were included in the meta-analysis to obtain a more precise estimation of the diagnostic value of CD147. The results showed that expression rate of CD147 in the GC group is higher than that in control group. Moreover, gender, TNM stage, lymph node metastasis, and depth of invasion are all associated with CD147. Further, sections of gastric tissue from 143 cases underwent immunohistochemical staining for evaluation of CD147 protein expression. Our retrospective analysis demonstrated CD147 protein expression was significantly associated with clinical N stage, and tumor stage. Meanwhile, it can also serve as an independent prognosis biomarker. In conclusion, our results support the role of CD147 as a good indicator of diagnosis and prognosis.
Highlights
Gastric cancer (GC) is one of the most common malignancies in the world and the second leading cause of global cancer death [1]
Our results indicated that expression rate of cluster of differentiation 147 (CD147) in the GC group was higher than that in the control group, and the difference between the two groups was statistically significant (OR = 12.80, 95% confidence intervals (CIs): 4.89 - 33.50, P = 0.000, I2 = 86.2%, Figure 2)
Our meta-analysis demonstrated that CD147 expressions in GC tissues were significantly higher than normal mucosa tissues (OR = 9.36, 95% CI: 2.09 - 42.00, P = 0.000, I2 = 89.3%, Figure 3A)
Summary
Gastric cancer (GC) is one of the most common malignancies in the world and the second leading cause of global cancer death [1]. Based on the latest statistical study in the USA, 24,590 new cases of GC were diagnosed, and 10,720 deaths caused by this disease were recorded in 2015 [2]. Genetic factor play an important role in the development of GC. Identification of factors that affect patient survival is critical for novel therapy development [4]. Meta-analysis can play a key role in generating new hypotheses [9]. Because the clinical role of CD147 expression in GC has not been extensively studied, a retrospective analysis of 143 cases was performed to explore the relationship between the expression level of CD147 protein and clinicopathological features (which contribute to the meta-analysis) as well as clinical prognosis in GC patients
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