Abstract
CD147 is correlated with tumor aggressiveness in various human malignancies. Here, we investigated CD147 protein expression in 223 patients with gastric cancer by immunohistochemistry and analyzed its association with disease-free and overall survival. CD147 was increased in gastric cancer compared to normal tissues. Additionally, CD147 expression was associated with gastric cancer invasion, metastasis and TNM stage, whereas it was not related to age, sex, differentiation status, tumor site or Lauren classification. Kaplan-Meier analysis confirmed that CD147 was associated with disease-free and overall survival in patients with gastric cancer; i.e., patients with positive CD147 staining tend to have worse disease-free and overall survival. Moreover, Cox's proportional hazards analysis demonstrated that CD147 was an independent marker of disease-free and overall survival for patients with gastric cancer. These results confirm the association of CD147 with gastric cancer invasion and metastasis and prove that CD147 might be an indicator of tumor recurrence and prognosis in gastric cancer.
Highlights
Gastric cancer is one of the most common human malignancies worldwide [1,2]
Disease-free survival is defined as the time elapsed from surgery to the first occurrence of any of the following events: recurrence of gastric cancer; gastric cancer distant metastasis; development of second non-gastric malignancy, excluding basal cell carcinomas of the skin and carcinoma in situ of the cervix; or death from any cause without documentation of a cancer-related event
CD147 Staining in Gastric Cancer In immunohistochemistry assay results, CD147 staining was mainly localized at the cell membranes and in the cytoplasm of gastric cancer cells
Summary
Gastric cancer is one of the most common human malignancies worldwide [1,2]. The highest rates of gastric cancer are in Eastern Asian countries. 42% of male and 19% of female gastric cancer patients throughout the world are found in China, where gastric cancer constitutes the third leading cause of cancer-related death [3,4]. Surgical resection is still the main treatment for gastric cancer. Approximately 60% of patients with gastric cancer have locally advanced and metastatic disease at the time of surgery, resulting in a relatively low therapeutic efficacy with surgical resection. The degradation of the extracellular matrix (ECM) is critical for gastric cancer cells to invade into surrounding tissue. Recent studies focusing on the mechanisms underlying gastric invasion suggest that matrix metalloproteinases (MMPs) play a critical role in this process [5]
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