阿尔茨海默病外周血单核细胞CD14与小胶质细胞的关系

Abstract

阿尔茨海默病(Alzheimer’s disease, AD)是老年人常见的一种神经退行性疾病。AD发病机制还不是很清楚，研究发现淀粉样蛋白沉积激活神经胶质细胞所导致的炎症反应是其核心病理机制。近期研究表明CD14信号传导通路及其基因多态性在小胶质细胞(Microglia, MG)激活过程中发挥着一定的作用。本文主要就近年来阿尔茨海默病人外周血单核细胞(peripheral blood mononuclear cell, PBMC)中CD14细胞与MG之间关系的研究进行综述。 Alzheimer’s disease is a neurodegenerative disease common in older people. Alzheimer’s disease pathogenesis is not very clear; the research found that the inflammation of amyloid deposition caused by activation of glial cells is the core pathogenesis. Recent studies show that the CD14 signal transduction pathway and gene polymorphism in microglia activation plays a role in this paper research in recent years. The relationship between CD14 cells and MG in Alzheimer’s patients in peripheral blood mononuclear cells was reviewed.