Abstract
Angiogenesis is the process of generating new capillary blood vessels from pre-existing vesscels and a fundamental process in the normal development, reproduction, and wound healing. Since neovascularization in physiological processes is tightly regulated by a balance of angiogenic and anti-angiogenic factors, unregulated angiogenesis may lead to several angiogenic diseases and is thought to be indispensable for tumor growth and metastasis. A growing tumor relies on angiogenesis to receive an adequate supply of nutrients and oxygen. In addition, the newly formed blood vessels provide a way for tumor cells to enter the circulation and to metastasize to distant organs.
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