Abstract
Background & Objective:CD137 is a member of the TNF-Receptor family. TNF-alpha antagonists have therapeutic effect in active psoriasis. In this study, the relative frequency of CD137 expression was investigated in the inflammatory cells of psoriasis lesions for the first time. Methods:The specimens were obtained from pathology department of Al-Zahra hospital from paraffin-embedded skin specimens collected from 2007 till 2016. . A total number of f 64 psoriasis skin specimens and 34 normal skin specimens were reviewed for the diagnosis. Then, the immunohistochemical staining for CD137, CD4, and CD8 was performed. Results:CD137 expression of dermal inflammatory cells in psoriasis lesions was 11.19±5.5%. Although, in normal skin tissues, CD137 expression was observed in 1.3±3.03% of the inflammatory cells. (P=0.001). The relative frequency of the CD137 positive inflammatory cells was significantly higher in the epidermis compared to dermis (epidermis: 31.1%±12.8, dermis 11.1%±5.5). There was no remarkable relation between the CD137 expression rate and the CD4: CD8 ratio. Conclusion:CD137 as a TNF-alpha receptor has a significant role in pathogenesis of the psoriasis lesions. Therefore, CD137 antagonists can be considered as a novel target for the treatment of incurable psoriasis patients.
Highlights
Psoriasis is a chronic papulosquamous dermatitis with different ranges of incidence of 0.91 to 8.5% and 0 to 2.1% among adult and children, respectively [1]
CD137 expression was extremely rare in the normal skin specimens
11.1±5.5% of inflammatory cells within the psoriasis skin lesions exhibited positive cytoplasmic CD137 expression, but this was 1.3±3.03% for normal skin specimens (P=0.001)
Summary
Psoriasis is a chronic papulosquamous dermatitis with different ranges of incidence of 0.91 to 8.5% and 0 to 2.1% among adult and children, respectively [1]. The mean age of onset is around 25 years, people in all age groups can be affected [2]. It is typically characterized by erythematous thick silverwhite plaques on the scalp, trunk, and extensor surface of extremities. Psoriasis has some histopathological characterizations including epidermal hyperplasia, hyperkeratosis, parakeratosis, spongiform pustules of Kogoj, supra-papillary thinning of granular layer, dermis capillary proliferation, and inflammatory infiltrate in dermis [3]. Epidermal hyperplasia and altered keratinocyte differentiation are prominent in this disease, many studies have demonstrated the immune system is the main player in its pathogenesis [4,5,6]. TNFalpha antagonists have therapeutic effect in active psoriasis. The relative frequency of CD137 expression was investigated in the inflammatory cells of psoriasis lesions for the first time
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