Abstract
Background: There are few evidence which kind of tumor is more benefit from cetuximab, more investigations of supplementary predictive factors are highly relevant. The purpose is to evaluate the prognostic significance of CD133 expression and to investigate the utility as biomarker of prognosis of metastatic colorectal cancer (mCRC) patients treated with cetuximab. Methods: We investigated progression-free survival (PFS) and overall survival (OS) of patients with mCRC about 5FU-based regimen as first line chemotherapy and cetuximab as salvage line retrospectively, and performed immunohistochemical staining to evaluate the CD133 status. Non-parametric statistics, univariate and multivariate analysis were used. Results: From October 2008 to June 2009, 46 patients with measurable mCRC had received cetuximab as salvage line, and all of them had treated with 5FU-based regimen as first line. In first line chemotherapy, the median OS was 33.1 months (95% CI, 25.6-40.4) in the CD133-positive patients as compared with 16.0 months (95% CI, 0.938-31.1) in the CD133-negative patients (P=0.004), but there were no statistically significant difference in PFS between both group. In salvage therapy with cetuximab, the median OS was 8.8 months (95% CI, 5.24-12.4) in the CD133-positive patients as compared with 5.1 months (95% CI, 3.23-6.90) in the CD133-negative patients (P=0.007). The median PFS was also significantly better in CD133-positive patients, with a median of 5.2 month (95% CI, 2.96-7.51) in the CD133-positive patients as compared with 2.8 month (95% CI, 1.48-4.06) in CD133- negative patients (P=0.046). Univariate and multivariate Cox proportional hazards regression was performed, and it is shown that CD133 predicted OS and PFS of cetuximab. Conclusions: CD133 status was correlated with the prognosis of patients
Highlights
Significant improvements have been achieved in the treatment of metastatic colorectal cancer with the development of new regimens such as FOLFOX and FOLFIRI
Relationship between CD133 status and prognosis in metastatic colorectal cancer (mCRC) patients treated with cetuximab
The purpose of this study was to evaluate the prognostic significance of CD133 expression as a biomarker in mCRC patients treated with cetuximab in combination chemotherapy
Summary
Significant improvements have been achieved in the treatment of metastatic colorectal cancer (mCRC) with the development of new regimens such as FOLFOX and FOLFIRI. Some of these new therapeutic agents are molecularly-targeted such as those against monoclonal antibody against epidermal growth factor receptor (EGFR) or vascular endothelial growth factor. On which type of tumor is more likely to respond to cetuximab, indicating the urgent need for further study to determine supplementary predictive factors. There are few evidence which kind of tumor is more benefit from cetuximab, more investigations of supplementary predictive factors are highly relevant. The purpose is to evaluate the prognostic significance of CD133 expression and to investigate the utility as biomarker of prognosis of metastatic colorectal cancer (mCRC) patients treated with cetuximab
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