Abstract
Aims and ObjectivesTo investigate the expression of CD10 and osteopontin in dentigerous cyst and ameloblastoma and to correlate their expression with neoplastic potentiality of dentigerous cyst and local invasion and risk of local recurrence in ameloblastoma.MethodsCD10 and osteopontin expression was studied by means of immunohistochemistry in 9 cases of dentigerous cysts (DC) and 17 cases of ameloblastoma. There were 7 unicystic ameloblastoma (UCA) and 10 multicystic ameloblastoma (MCA). Positive cases were included in the statistical analysis, carried on the tabulated data using the Open Office Spreadsheet 3.2.1 under Linux operating system. Analysis of variance and correlation studies were performed using "R" under Linux operating system (R Development Core Team (2010). Tukey post-hoc test was also performed as a pair-wise test. The significant level was set at 0.05.ResultsHigh CD10 and osteopontin expression was observed in UCA and MCA, and low CD10 and osteopontin expression was observed in DC. Significant correlation was seen between CD10 and osteopontin expression and neoplastic potentiality of DC and local invasion and risk of recurrences in ameloblastoma.ConclusionsIn DC, high CD10 and osteopontin expression may indicate the neoplastic potentiality of certain areas. In UCA & MCA, high CD10 and osteopontin expression may identify areas with locally invasive behavior and high risk of recurrence.
Highlights
Dentigerous cyst (DC) is the most common developmental cyst in the oral cavity, accounting for 20% of the developmental cysts of the jaws, and is almost always associated with the crown of a tooth attached to the cemento-enamel junction
Ameloblastoma is an uncommon benign, locally aggressive odontogenic neoplasm that accounts for approximately 10% of all tumors that arise in the mandible and maxilla [2]
Nine cases were diagnosed as dentigerous cyst, seven cases were diagnosed as unicystic ameloblastoma, and ten cases were diagnosed as multicystic ameloblastoma
Summary
Dentigerous cyst (DC) is the most common developmental cyst in the oral cavity, accounting for 20% of the developmental cysts of the jaws, and is almost always associated with the crown of a tooth attached to the cemento-enamel junction. It is believed to originate from the accumulation of fluid between the reduced enamel epithelium and the tooth crown, expanding the follicle beyond the 3 mm normal diameter and is usually associated with impacted or un-erupted teeth [1]. Ameloblastoma is an uncommon benign, locally aggressive odontogenic neoplasm that accounts for approximately 10% of all tumors that arise in the mandible and maxilla [2]. The etiology is unknown, ameloblastoma is believed to develop from various sources of odontogenic epithelia, including dental follicular lining epithelium [3]. CD10 is expressed on the surface of a variety of normal and neoplastic hematopoietic and lymphoid cells, including lymphoid precursor cells, germinal center B lymphocytes and some epithelial cells [7]
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