Abstract
2+ ) a common pollutant and known toxicant, and other various anti cancer drugs such as 5-fluorouracil bind to DNA competitively. Their efficacy as anti cancer drugs was brought by their mechanism of involvement with DNA and their interactive geometries. In this perspective we have designed CD spectral studies to investigate the interference of Pb 2+ with DNA-Drug interaction geometries. The change in elliptical intensities at around 260 nm to 280 nm and 245 nm shows the conformational changes in B-form of DNA. Amplitude changes observed with in B-form indicates the hairpin formation which is an intra-molecular variant of the B-form. Calf thymus DNA with 42% of G-C content has tendency towards hairpin transitions. In this study we have found that hairpin transitions might be involved in mechanism of Pb 2+
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More From: International Journal of Biochemistry and Biophysics
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