Abstract
The natural γ-cyclodextrin (γCD) is like linear water-soluble dextrins, and unlike the natural α- and β-cyclodextrins (αCD and βCD), digested by salivary and pancreatic amylase. This gives γCD a very favorable toxicological profile. However, its usage is hampered by its relatively low solubilizing effect and tendency to form turbid solutions. Addition of 2-hydroxypropyl-γ-cyclodextrin (HPγCD) to aqueous γCD solutions increases the complexation efficiency of γCD and reduces the turbidity. For example, 80:20 mixture of γCD and HPγCD is up to 50% more effective solubilizer for dexamethasone and hydrocortisone than expected based on the solubilizing effects of the individual cyclodextrins. Mixing αCD or βCD with their more water-soluble derivatives only resulted in additive effects. Mixing γCD with HPγCD resulted in synergistic effect.
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