Abstract
Objective P-type atypical lymphocytes may play important roles in the etiology and therapy of schizophrenia. However, there is merely a direct immunological characterization of it. The aim of this study is to explore the surface antigens of these cells and their comparative ultrastructure in schizophrenia. Methods We recruited 25 age-and gender-matched patients with unmedicated schizophrenia, other mental diseases and healthy individuals. Peripheral venous blood was smeared and stained. CD4+, CD8+ and CD19+ cell surface antigen- positive lymphocytes were purified using magnetic beads and prepared for light microscopy and electron microscopy. Results The percentages of P-type atypical lymphocyte (34.53% ± 9.92%) were significantly higher (P <0.0001) in schizophrenia than that of other mental diseases (9.79% ± 3.45%) . These cells could present CD4+, CD8+ and CD19+ surface antigens. Their relative ultrastructure differed from that of normal lymphocytes, especially in mitochondria, which showed abundant, aggregated and quite irregular mitochondria, for example, slight dilation of the foci, swelling, degeneration, and even cavity. Conclusions P-type atypical lymphocytes could be found among CD4+, CD8+, and CD19 + lymphocytes with schizophrenia. Their abnormal ultrastructure of mitochondria implied that energy metabolism might play an important role in the etiology of schizophrenia.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
