Abstract
To understand the mechanisms underlying the Cd 2+- and Co 2+-induced intracellular Ca 2+ mobilization, we measured the levels of inositol phosphates using bovine chromaffin cells. Studies using HPLC indicated that Cd 2+, Co 2+ and methacholine significantly increased the generation of 1,4,5-IP 3. The results suggest that Cd 2+ and Co 2+ mobilize Ca 2+ from IP 3-sensitive Ca 2+ stores, possibly through the presumptive Cd 2+ receptor.
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