鼠らい感染動物に見られる臓器内c型cytochrome濃度ならびに遊離amino酸成分比の変動について

Abstract

The concentrations of c type cytochrome and the proportions of free amino acid in various organs of mice, intraperitoneally inoculated with murine leprosy bacillus were determined along the periods of time after inoculation.1) The c type cytochrome concentrations in spleen and kidney of the infected mice were found to be higher than that of normal mice, on the date from 4th day until 5th week after inoculation. On the 15th and 30th week after inoculation, however, the c type cytocrome concentrations in liver, spleen and indey of the infected mice, the most of which were suffered from several leproma grown in their abdomen, were found to be reduced less than 65-78% of the normal levels.2) The following changes in the proportions of free amino acid in liver, spleen and kidney of the infected mice were observed: On the 3rd week after inoculation, spleens of the almost inoculated mice were enlarged extremely, and their contents of Glu., Thr. and Cys. increased, while Gly., Ala. and Leudecreased.The content of Cys. in liver of the infected mice on the 5-15th week after inoculation were found to decrease. On the 15th and 30th week, the content of Glu. in the infected liver were found to increase, while the content of Ala. decreased.According to the results as mentioned above, especially, the remarkable changes in free amino acid proportions of Glu., Ala., Gly. and Ser. in the organs of infected mice, the occurence of disturbances concerning lipid and carbohydrate metabolism as well as protein metabolism could be assumed in the mouse body infected with murine leprosy bacillus.