Abstract
Graft-versus-host disease (GVHD), a common complication that is caused by donor T cells following allogeneic hematopoietic cell transplant (HCT). The function of CCR5 in GVHD has been primarily explored in murine models and the data suggested a complicated role of CCR5 in alloimmmune responses. We have identified unrelated MHC-matched HCT donors genetically lacking CCR5 (CCR5δ32) and correlated presence or absence of CCR5 with HCT outcomes. Patients were 18-50 years old, and they received cyclophosphamide and fractionated total body irradiation, unmanipulated marrow, and GVHD prophylaxis with cyclosporine and methotrexate.
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