Abstract
Orchestrated trafficking and activation by pathogen-derived peptides define the ability of CD4+ T helper cells to contribute to an effective adaptive immunity. In this issue of The EMBO Journal, Martín-Leal etal show that the inflammatory chemokine receptor CCR5, well known for its role in cell migration and HIV infection, regulates ceramide synthesis and TCR nanoclustering to promote memory CD4+ T cell activation.
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