Abstract
The influence of TDT administration in vivo on the changes of two enzymic activities in the liver cell membranes damaged by C Cl4 was observed. The following results were obtained. 1) In normal rats, TDT had no significant effect on NADH-cytochrome c reductase and ATPase activities in membranes or microsomes. 2) TDT was capable of preventing not only the changes of NADH-cytochrome c reductase and ATPase activities in cell membranes produced by C Cl4 administration, but also the leakage of NADH-cytochrome c reductase into plasma. 3) TDT did not modify the body temperature in normal rats and that induced by C Cl4, neither. 4) The mechanism of action of TDT was discussed.
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