Abstract
Background and Aims: Immune cells, particularly T-lymphocytes, play a critical role in atherosclerotic plaques’ progression and destabilization leading to myocardial infarctions and strokes. Chemokine binding was proposed to drive T-cell accumulation in plaques. We analysed the chemokine receptor signatures of T-cells isolated from 17 atherosclerotic plaques from 13 patients and compared them with autologous peripheral blood T-cells. Also, the chemokine expression levels in plaque tissue were compared with those in peripheral blood cells.
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