Abstract
CCL28 induces mucosal homing of HIV-1-specific IgA-secreting plasma cells in mice immunized with HIV-1 Virus-like Particles
Highlights
MEC/CCL28 (CCL28) binds to CCR3 and CCR10 and recruits IgA-secreting plasma cells (IgA-ASCs) in the mucosal lamina propria
CCL28 induces mucosal homing of HIV-1-specific IgA-secreting plasma cells in mice immunized with HIV-1 Virus-like Particles
The following parameters were significantly augmented in Virus-like Particles (VLPs)-CCL28 mice compared to control groups: the percentage and the surface density of CCR3 and CCR10 on CD19+ splenocytes; IFN-g, IL-4 and IL-5 production in splenocytes and mucosal specimens; total IgA titers in sera and in mucosal secretions; antigen-specific IgG and IgA titers in sera and in mucosal secretions
Summary
MEC/CCL28 (CCL28) binds to CCR3 and CCR10 and recruits IgA-secreting plasma cells (IgA-ASCs) in the mucosal lamina propria. Virus-like Particles (VLPs) are a novel vaccine approach based on non-pathogenic particles that mimic the structure of virus particles with effective induction of both arms of the immune response. The suitability of CCL28 as an adjuvant for the elicitation of optimal mucosal and systemic immunity was assessed in mice immunized with HIV-1 VLPs
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