CCL2/ACKR2 interaction participate in breast cancer metastasis especially in patients with altered lipid metabolism

Abstract

Breast cancer is the most prevalent cancer worldwide and metastasis accounts for the majority of associated deaths. Altered lipid metabolism has been proved to be involved with breast cancer, yet the underlying mechanism in lipid metabolism mediated metastasis in breast cancer remains inadequately understood. Evidence have indicated that adipocytes can produce chemokine ligand 2 (CCL2), and several studies have shown that tumor metastasis and patient survival is associated with atypical chemokine receptors/chemokine decoy receptors. We are interested in the factors that may influence cancer metastasis and patient prognosis, particularly in patients with altered lipid metabolism. In this paper, we propose a hypothesis that patients with increased expression levels of atypical chemokine receptor 2 (ACKR2) receptors will have less chance for tumor metastasis, whereas patients with decreased ACKR2 expression but high levels of chemokine receptor 2 positive (CCR2 + ) monocytes are more likely to develop metastasis and have worse outcomes. However, in patients with lower ACKR2 expression level but elevated level of CCR2 + NK cells, primary tumor can be suppressed and therefore present better outcomes.