Abstract
The experiment with rabbits was to show whether CHCl3 and C2H5OH were effective or not as the secondary or booster exposure of detecting inapparent industrial poisoning of CCl4. Results were as follows. (1) There appeared no change at all in plasma GPT activities when CHCl3 at 0.1cc/kg was administered to the normal rabbits. And after repeated administrations of a small dose of CCl4 for 5 weeks, there was no change in GPT activities either. Receiving booster injection of a single dose of CHCl3 at 0.1cc/kg the animals reacted to the dose by an apparent increase of plasma GPT activities this time. This result implies that CHCl3 was effective as a secondary or booster exposure to detect the inapparent poisoning of CCl4. (2) There was no change in plasma GPT activities when 50% C2H5OH at 10 cc/kg was subcutaneously injected to the chronically CCl4 poisoned rabbits. This result meant that C2H5OH was not effective as a secondary or booster exposure to detect the inapparent poisoning of CCl4. (3) The authors discussed that CCl4 and CHCl3 were effective as the secondary or booster exposure to detect the inapparent poisoning of CCl4, and that the action of CCl4 and CHCl3 upon the inapparently poisoned animals had not yet been confirmed.
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