Abstract
CCK1 antagonists: Design, Synthesis and Evaluation of N-Substituted Isobuyl-5-Hydroxy-5-Phenyl-Pyrrol-2- Ones as Adjunct to Opiates
Highlights
In terms of cholecystokinin-physiology, CCK8 is the most common peptide hormone, which is extensively found throughout the gastrointestinal tract and is widely distributed through the nervous system [1,2]
Cholecystokinin antagonists have been extensively investigated as potential drug targets [6]
5-arylated dichloro-2(5H)-furanones A and B were synthesised from mucochloric acid (Figure 2), which is commercially available from furfural under oxidising conditions with hydrochloric acid
Summary
In terms of cholecystokinin-physiology, CCK8 is the most common peptide hormone, which is extensively found throughout the gastrointestinal tract and is widely distributed through the nervous system [1,2]. Cholecystokinin was discovered to cause contractions of the gallbladder [3]. It was rediscovered as pancreozymin, triggering the release of pancreatic enzymes. CCK-ligands, agonists and antagonists have been extensively investigated as potential drug molecules [5]. Cholecystokinin antagonists have been extensively investigated as potential drug targets [6]. They were studied as growth inhibitors in certain forms of cancer, as anxiolytics, in the treatment of schizophrenia and satiety [7,8,9,10]. Cholecystokin in does cause proliferation in colon- and pancreatic cancer cell lines and CCK-antagonists were studied as growth factor inhibitors in certain forms of cancer
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Organic & Medicinal Chemistry International Journal
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
