Abstract
The novel 3-ureidobenzazepin-2-ones 11 and 12, which incorporate a cationic substituent at the 5-position were designed and synthesised as ligands for the CCK B receptor. These compounds proved to have high affinity for the CCK B receptor and were selective over the CCK A receptor subtype. This work further defines the role of the benzazepine template as a bioisostere for the 1,4-benzodiazepine template of earlier CCK antagonists.
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