Abstract
Recent studies showed leucine-rich-alpha-2-glycoprotein 1(LRG1) is associated with multiple malignancies. They reported that the silencing of this protein could enhance migration and invasion of tumor cells in vitro, however underlying roles of this protein in tumor biology are still unknown. Then, we studied the expression level of LRG1 in brain tumors and serum in brain tumor-bearing animals. We inoculated KT-3 cells, mouse glioma cell line, into the striatum of C57BL mouse and sacrificed animals at the day 5, 10, and 14 days after the inoculation day. The expression level of LRG1 were evaluated with quantitative real-time PCR and immunohistochemical staining and the serum level of LRG1 were also studied with enzyme-linked immunosorbent assay (ELISA). We revealed that the serum level of LRG1 in brain tumor-bearing animals was relatively high when compared with no brain tumor-bearing animals and the expression of LRG1 in tumors were related to the time course of tumor growing. To the best of our knowledge, our study is one of the first studies reporting the expression data of LRG1 in tumors and the level in serum in tumor-bearing animals.
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