Abstract
Caveolae are membrane domains that provide mechanical strength to cells to localize signaling molecules. These invaginations are composed of caveolin-1 or −3 (Cav1/3) molecules that assemble into domains with the help of cavin-1. Besides organizing caveolae, cavin-1 also known as polymerase I and transcript release factor (PTRF), promotes ribosomal RNA transcription into the nucleus. Here, we find that deforming caveolae by subjecting cells to mild osmotic stress (300 to 150 mOsm), changes levels of GAPDH, HSP90 AND Ras only when Cav1/cavin-1 levels are reduced suggesting link between caveolae deformation and protein expression.
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