Abstract
To the Editor: Recently, Aldons Lusis and coworkers suggested a relationship between stearoyl-coenzyme A (CoA) desaturase-1 (SCD1) activity and familial combined hyperlipidemia (FCH).1 The relationship between SCD1 and metabolic features related to FCH has attracted interest because it was shown that the SCD1 knockout mouse is obesity-resistant on high-fat feeding and has increased insulin sensitivity.2 The surrogate marker used for SCD1 activity is often the ratio of the product and precursor for the SCD1 enzymatic step, ie, either the ratio between 16:1n-7 and 16:0 or that of 18:1n-9 and 18:0 in plasma samples. Not only is this ratio very much dependent on previous food intake, it is also influenced by the fraction of lipids in plasma in which …
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