Abstract
Anticonvulsive effects and changes in chemical species reflecting nitric oxide production (NOx levels) were induced in the EL mouse by a solvent mixture commonly used to dissolve antiepileptic drugs. The mixture consisted of porpylene glycol (PG) and ethanol in saline (PES), and included 10.5% ethanol plus 20, 40, or 60% PG. PES mixtures suppressed seizures in EL mice in proportion to concentrations of PG. NOx levels in the brains of mice treated with PES mixtures including 40 or 60% PG were significantly lower than in control mouse brain. These results suggested that anticonvulsive effects of PES mixtures were related to reduction of NOx levels in brain. PG should not be used as a drug solvent in epilepsy research.
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