Abstract
Frailty is an important and common geriatric syndrome, yet the mechanisms are multifactorial and not well understood. The Frailty Index (FI) is based on the Rockwood Index for accumulation of deficits, and we aimed to use genetics to gain mechanistic insights for interventions to prevent and delay frailty in older people. We performed a genomewide association study in 60 to 70 year old UK Biobank participants of European descent (n=164,610). We identified 26 independent genetic signals at 24 loci associated with the FI. Several of these signals have previously been associated with traits such as cardiovascular disease, intelligence, and educational attainment, but 6 of the signals appear to be novel. We will also present the results of ongoing work both to identify causal risk factors for FI using Mendelian randomization methods, and replication and functional follow-up in the TwinGene cohort, at the meeting.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
