Causes and Outcomes of Acute Chest Syndrome in Sickle Cell Disease

Abstract

Pulmonology/Critical Care| September 01 2000 Causes and Outcomes of Acute Chest Syndrome in Sickle Cell Disease AAP Grand Rounds (2000) 4 (3): 17–18. https://doi.org/10.1542/gr.4-3-17 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Causes and Outcomes of Acute Chest Syndrome in Sickle Cell Disease. AAP Grand Rounds September 2000; 4 (3): 17–18. https://doi.org/10.1542/gr.4-3-17 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search nav search search input Search input auto suggest search filter All PublicationsAll JournalsAAP Grand RoundsPediatricsHospital PediatricsPediatrics In ReviewNeoReviewsAAP NewsAll AAP Sites Search Advanced Search Topics: acute chest syndrome, sickle cell anemia, fat embolism Source: Vichinsky EP, Neumayr LD, Earles AN, et al. Causes and outcomes of the acute chest syndrome in sickle cell disease. National Acute Chest Syndrome Study Group. N Engl J Med. 2000;342:1855–1865. Thirty United States centers evaluated 671 episodes of acute chest syndrome (ACS) in 538 patients from 1993–1997 in this prospective study to determine the cause, outcome, and response to therapy. ACS was defined as a new pulmonary infiltrate on chest radiograph in association with chest pain, temperature elevation (>38.5°C), tachypnea, wheezing, or cough in a patient known to have hemoglobin SS, SC or SS-beta thalassemia and at least one prior episode of ACS. Patients were treated with a standardized protocol including oxygen, antibiotics, fluid management, respiratory therapy and bronchodilators, pain management, and transfusion therapy. Laboratory evaluations included blood counts, blood gases, chest radiographs, pulmonary function testing, viral cultures, bacterial cultures, serologies (for Mycoplasma... You do not currently have access to this content.