Abstract
Abnormalities in liver function tests appear in 3% of pregnancies. Severe acute liver damage can be an exclusive condition of pregnancy (dependent or independent of pre-eclampsia) or a concomitant disease. HELLP syndrome and acute fatty liver of pregnancy are the most severe liver diseases associated with pregnancy. Both appear during the third trimester and have a similar clinical presentation. Acute fatty liver may be associated with hypoglycemia and HELLP syndrome is closely linked with pre-eclampsia. Among concomitant conditions, fulminant acute hepatitis caused by medications or virus is the most severe disease. Its clinical presentation may be hyper-acute with neurological involvement and severe coagulation disorders. It has a high mortality and patients should be transplanted. Fulminant hepatic failure caused by acetaminophen overdose can be managed with n-acetyl cysteine. Because of the high fetal mortality rate, the gestational age at diagnosis is crucial.
Highlights
El embarazo es un estado durante la vida de la mujer que conlleva una serie de adaptaciones fisiológicas con el fin de favorecer el desarrollo fetal (Tabla 1)
Ambas entidades se caracterizan por afectar preferentemente en el tercer trimestre (3T) de la gestación
Jarufe N, Soza A, Pérez-Ayuso RM, Poblete JA, González R, Guajardo M, et al Successful liver transplantation and delivery in a woman with fulminant hepatic failure occurring during the second trimester of pregnancy
Summary
Actualización en el diagnóstico y manejo del daño hepático agudo grave en el embarazo Alvaro Sepulveda-Martinez[1], Carlos Romero[2], Guido Juarez[1], Jorge Hasbun[1], Mauro Parra-Cordero[1]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
