Abstract
It is well established that obesity is related to osteoarthritis of the knees. The aim of this study was to investigate the risk of knee osteoarthritis in relation to body mass index (BMI) and specifically, to assess the risk of knee osteoarthritis (OA) attributable to obesity. We also aimed to determine if there is a higher risk with an increase in BMI. This is an observational case-referent study of patients with knee pain. Patients were recruited from the orthopaedics clinic. The cases were patients that presented with radiologically diagnosed knee osteoarthritis, while the referents were other patients that also attended the orthopedic clinic at the same time. The referents were randomly selected. Body Mass Index was calculated and classified based on the WHO international classification. Data were analyzed using SPSS version 21. A total of 152 patients were included in the study and 67.1% were females while 32.9% were males giving a ratio of 2:1. The mean age was 57.72+/-12.5 years, the mean weight was 79.47+/- 13.41kg (95% CI 77.32 – 81.62) and the mean BMI was 27.80+/-6.2kg/m2. 56.6% had knee osteoarthritis. 8.6% (n = 13) were bilateral, 18.4% (n = 28) in the left knee and 29.6% (n = 45) in the right knee. The relationship between obesity and the presence of knee osteoarthritis was statistically significant (p 0.047). A Chi-squared test for trend also did not show an increased risk for knee osteoarthritis with increasing BMI (p 0.105). In conclusion, knee osteoarthritis is a degenerative joint disease that mostly affects the elderly. Our findings give strong support to the already existing knowledge of the positive relationship between obesity and knee osteoarthritis; however, increasing BMI did not increase the risk of knee OA.
Highlights
Cause and Effect Relationship of Body Weight and Knee Osteoarthritis: Experience from a Tertiary Institution in
The mean age was 57.72+/-12.5 years, the mean weight was 79.47+/- 13.41kg and the mean body mass index (BMI) was 27.80+/-6.2(95% confidence intervals (CI) 26.81 – 28.80). 56.6% had knee osteoarthritis. 8.6% (n = 13) were bilateral, 18.4% (n = 28) in the left knee and 29.6% (n = 45) in the right knee. 67.1% had a BMI of greater than 30 while 32.9% had BMIs less than 30
As several studies point towards the role of obesity in knee OA, it becomes logical to inquire of the reverse role weight loss would have
Summary
Cause and Effect Relationship of Body Weight and Knee Osteoarthritis: Experience from a Tertiary Institution in. The aim of this study was to investigate the risk of knee osteoarthritis in relation to body mass index (BMI) and to assess the risk of knee osteoarthritis (OA) attributable to obesity. We aimed to determine if there is a higher risk with an increase in BMI This is an observational case-referent study of patients with knee pain. Some studies have shown that overweight women have nearly 4 times the risk of knee OA and for overweight men the risk is 5 times greater.[1] The purpose of this study, is to determine the risk of knee osteoarthritis in relation to body mass index (BMI) and to assess the risk of knee osteoarthritis (OA) attributable to obesity.
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