Abstract
The aim of this study was to investigate the causes of death among 129 AIDS patients that were autopsied at the Tropical Medicine Foundation of Amazonas between 1996 and 2003. The degree of concordance between the autopsy diagnoses and the clinical diagnoses was observed. The disease that most frequently caused death was tuberculosis (28%), followed by bacterial pneumonia (17%), histoplasmosis (13%), toxoplasmosis (10%), pneumocystosis (8%), cryptococcosis (5%), bacterial sepsis (4%) and other causes (15%). The concordance between the clinical diagnosis before death and the autopsy was 51.9%. The main organ involved was the lungs (82.2%). The length of survival from the time of the laboratory diagnosis to death ranged from one month to 120 months. The mean length of survival was 15 days and 56% died less than one month after the diagnosis, while 15 patients died on the same day that they were diagnosed. These results show the importance of autopsies in elucidating the causes of death among AIDS patients.
Highlights
The aim of this study was to investigate the causes of death among 129 AIDS patients that were autopsied at the Tropical Medicine Foundation of Amazonas between 1996 and 2003
As causas mais freqüentes do óbito foram tuberculose (28%), pneumonia bacteriana (17%), histoplasmose (13%), toxoplasmose (10%), pneumocistose pulmonar (8%), criptococose (5%), sepse bacteriana (4%), sarcoma de Kaposi, meningoencefalite viral, cirrose hepática e síndrome diarréica (2% cada) e leucemia linfocítica aguda, acidente vascular cerebral, meningite bacteriana, hepatite medicamentosa, linfoma, malária e pneumonia aspirativa com 1% cada (Tabela 1)
Em um estudo de coorte feito na Suíça em 2003, avaliando a causa do óbito em autópsias entre pacientes com AIDS que estavam sendo tratados com anti-retrovirais, foi encontrado, associada à mortalidade, pneumonia bacteriana (17%), pneumonia por Pneumocistis jiroveci (13%)
Summary
The aim of this study was to investigate the causes of death among 129 AIDS patients that were autopsied at the Tropical Medicine Foundation of Amazonas between 1996 and 2003. O objetivo deste estudo foi determinar as causas de morte em pacientes com AIDS, submetidos à necropsia no período de 1996 a 2003, na Fundação de Medicina Tropical do Amazonas (FMTAM), destacando-se as doenças que levam a óbito estes pacientes, avaliando o grau de concordância entre o diagnóstico clínico e o diagnóstico na necropsia, e ainda, caracterizar os fatores sócio-demográficos.
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