Abstract
Causal Genomic and Epigenomic Network Analysis emerges as a New Generation of Genetic Studies of Complex Diseases.
Highlights
Rapid advances in genomic technologies have dramatically changed the genetic studies of complex diseases
Numerous studies reported that the genetic loci identified by Genome-wide association studies (GWAS) collectively explain only < 10% of genetic variation across the population in most complex diseases
Extremely large number of samples are collected and whole genome sequencing studies will be conducted very soon, which will lead to reducing he fraction of missing heritability, a large proportion of heritability will be still missing under the paradigm of single trait genetic analysis
Summary
Rapid advances in genomic technologies have dramatically changed the genetic studies of complex diseases. Genome-wide association studies (GWAS) have been widely used in dissecting genetic structure of complex diseases. As of December 18th, 2014, A Catalog of Published Genome-Wide Association Studies (GWAS) had reported significant association of 15,177 SNPs with more than 700 traits in 2,087 publications [1].
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