Causal Brain Network in Clinically-Annotated Epileptogenic Zone Predicts Surgical Outcomes of Drug-Resistant Epilepsy.

Abstract

Patients with drug-resistant epilepsy (DRE) are commonly treated using neurosurgery, while its success rate is limited with approximately 50%. Predicting surgical outcomes is currently a prominent topic. The DRE is recognized as a network disorder involving a seizure triggering mechanism within epileptogenic zone (EZ); however, a systematic exploration of the EZ causal network remains lacking. This paper will advance DRE study by: (1) developing a novel causal coupling algorithm, "full convergent cross mapping (FCCM)" to improve the quantization performance; (2) characterizing the DRE's multi-frequency epileptogenic network by FCCM calculation of ictal iEEG; (3) predicting surgical outcomes using network features and machine learning. Numerical validations demonstrate the FCCM's superior quantization in terms of nonlinearity, accuracy, and stability. A multicenter cohort containing 22 DRE patients with 81 seizures is included. Based on the Mann-Whitney-U-test, coupling strength of the epileptogenic network in successful surgeries is significantly higher than that of the failed group, with the most significant difference observed in α -iEEG network (p = 1.52e - 07 ) Other clinical covariates are also considered and all th α -iEEG networks demonstrate consistent differences comparing successful and failed groups, with p = 0.014 and 9.23e - 06 for lesional and non-lesional DRE, p = 2.32e - 05, 0.0074 and 0.0030 for three clinical centers CHFU, JHU and NIH. Using FCCM features and 10-fold cross validation, the SVM achieves the highest accuracy of 87.65% in predicting surgical outcomes. The epileptogenic causal network is a reliable biomarker for estimating DRE's surgical outcomes. The proposed approach is promising to facilitate DRE precision medicine.