Causal association between plant foods intake and Alzheimer's disease: a Mendelian randomization study

Abstract

ABSTRACT Background Alzheimer's disease (AD) is a degenerative disease of the nervous system. Observational studies have found an association between plant food intake and AD. However, it is unclear whether this association is influenced by confounding factors. We aimed to explore the causal relationship between plant-based diet and the risk of AD using two-sample Mendelian randomization. Materials and Methods We obtained datasets of exposure from the IEU Open GWAS project, including dried fruit intake, fresh fruit intake, raw vegetable intake, cooked vegetable intake, and cereal intake. The summary data for AD were obtained from a large GWAS meta-analysis containing 71,880 cases and 383,378 controls. Results Increased intake of dried fruits was associated with a reduced risk of AD (IVW: OR = 0.88, 95CI = 0.82–0.95). No causal association was found between the intake of other foods and AD. Conclusion This MR study suggests that genetically predicted increased intake of dried fruits is a causal protective factor for AD.