Abstract
Caudal regression syndrome is a rare congenital abnormality in which a segment of the spine and spinal cord fails to develop. The severity of the morphologic derangement inversely correlates with residual spinal cord function [1]. Cases of lower spine agenesis with additional anomalies of the axial skeleton and internal organs are now considered as defects of blastogenesis, originating in the primary developmental field and/or the progenitor fields, representing polytopic field defects. Sacral agenesis or caudal dysplasia is an anomaly found more often in offspring of diabetic women. Severe forms are commonly associated with cardiac, renal and respiratory problems, which are responsible for early neonatal death.
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