Abstract
Cationic titanium(IV) phenolato complexes with a pyridinium ligand were synthesized from their isopropoxo precursors, and featured improved solubility in water/DMSO solutions. High cytotoxicity was recorded toward HT-29 cells, often higher than that of cisplatin. Marked activity enhancement was observed upon substitution with pyridinium ligand, which improved the complexes biological accessibility.
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