Abstract
The synthesis and characterization of the complexes [PdX(PPh 3 )(4-MeT)]X (4-MeT = 4-methyl-3-thiosemicarbazide; PPh 3 = triphenylphosphine; X = Cl, Br, I, SCN) have been described. The complexes were evaluated for in vitro activity as cytotoxic agents on tumor cells and also as cathepsin B and topoisomerase I and II inhibitors. • Cationic palladium compounds were prepared bearing thiosemicarbazide and triphenylphosphine. • The compounds were more cytotoxic than cisplatin against LM3 and MCF-7 tumor cells. • The complexes interact with topoisomerase II more efficiently than etoposide. • Cathepsin B activity is inhibited by Pd(II) compounds.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
