Abstract
Biofilms Antibiotics are far more effective if the bacteria they target have not formed a biofilm, a structure held together by an extracellular matrix composed of a variety of polysaccharides, proteins, and other biomolecules, through weak interactions such as hydrogen bonds, van der Waals interactions, and ionic contacts. Joseph et al. show that the formation of biofilms by several Gram-positive bacteria is inhibited by cationic pillarenes, small ring compounds that link five or six aryl groups. The ring interior could interact with hydrophobic contacts, and substituted quaternary ammonium groups on the exterior faces could disrupt ionic contacts. Because these molecules are not antimicrobial, they should not inhibit beneficial gut bacteria. J. Am. Chem. Soc. 10.1021/jacs.5b11834 (2016).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
