Abstract
Synthesis of cationic reactive primary amine-functionalized diblock copolymer nano-objects via polymerisation-induced self-assembly (PISA) using a RAFT aqueous dispersion polymerisation formulation is reported.
Highlights
Primary amine-based polymers are of great interest as the result of their use in a wide range of applications such as drug delivery,[1,2] biomedical applications,[3,4] polypeptide synthesis[5,6,7] and biomineralisation.[8,9] Two important characteristics are their cationic character and their reactivity
For such polymerisationinduced self-assembly (PISA) syntheses via reversible-addition fragmentation chain transfer polymerisation (RAFT) aqueous dispersion polymerisation, a large batch of purified macro-CTA is initially prepared to enable a series of chain extension experiments targeting a wide range of core-forming block degree of polymerisation (DP)
Systematic variation of the degree of polymerisation (DP = 100–1000) of the core-forming PHPMA block at 10% w/w solids leads to the formation of cationic spherical nanoparticles, with mean particle diameters ranging from 68 to 288 nm
Summary
Primary amine-based polymers are of great interest as the result of their use in a wide range of applications such as drug delivery,[1,2] biomedical applications,[3,4] polypeptide synthesis[5,6,7] and biomineralisation.[8,9] Two important characteristics are their cationic character and their reactivity. The Despite considerable interest, the synthesis of well-defined primary amine methacrylate-based polymers with precise molecular weights and low polydispersities has proven to be a difficult synthetic challenge. This is because 2-aminoethyl methacrylate (AMA) rapidly undergoes molecular rearrangement to form 2-hydroxyethyl methacrylamide in its deprotonated form (i.e. at high pH).[17] In principle, this problem can be overcome by protecting the monomer prior to its polymerisation; this approach requires additional protection/ deprotection steps and is both time-consuming and atom-inefficient..
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