Abstract
The murine erythroleukemia (MEL) cell system has served as an important in vitro model for the process of erythroid differentiation for the past decade. Under a controlled set of experimental conditions, MEL cells can be induced to undergo a program of terminal erythroid differentiation which closely resembles the process of normal murine erythropoiesis. MEL cells were originally derived from the spleens of mice infected with Friend virus complex. These virally transformed cells can be grown indefinitely by serial passage in tissue culture medium, but become committed to undergo a program of terminal erythroid differentiation when challenged with dimethylsuIfoxide (DMSO) or a wide variety of other agents.
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