Abstract

ABSTRACT Adsorptive stripping voltammetry is used for determination of trace levels of captopril in phosphoric acid (pH 2.3). The adsorptive peak was observed at −0.49 V vs. Ag/AgCl. The peak response was characterized with respect to pH, preconcentration time, possible interferences, deposition potential, supporting electrolytes and other variables. The obtained results were analyzed and the statistical parameters were calculated. Also the method was applied to determine the mentioned drug in pharmaceutical formulations, urine and blood-serum. The limit of detection was 0.019 ng/ml.

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