Catheterization of the lumbar subarachnoid space for long-term CSF collection in unanesthetized nonhuman primates

Abstract

Chronic indwelling spinal catheters facilitate administration of drugs and serial sampling of cerebrospinal fluid (CSF). Most catheters used in primates enter the ventricles or rostral subarachnoid space. This paper describes a procedure for catheterizing the lumbar subarachnoid space. Although the technique is invasive, maintenance and utilization of the catheter do not disturb the subject. The preparation remains patent for up to 21 days and permits both intrathecal drug administration and collection of CSF samples from unanesthetized subjects.