Catheter direct thrombolysis: Role of actilyse in treatment of acute deep venous thrombosis

Abstract

PurposeTo evaluate the short and long term efficiency of catheter directed thrombolysis using recombinant tissue type plasminogin activator (r-TPA; Actilyse), in treating acute deep venous thrombosis of the lower limb. Material and methodsTwenty-eight patients with acute lower limb deep venous thrombosis underwent treatment by direct intra clot injection of thrombolytic therapy; Actilyse. ResultThrombus lysis was completed in 23 (82.2%) of 28 patients, partial in 4 (14.3%) patients and not achieved in one (3.5%) patient. There was no major complication. There was no rethrombosis or post thrombotic syndrome in any of the treated 23 patients over the follow up period of one year. ConclusionThe treatment of acute lower limb deep venous thrombosis using recombinant tissue type plasminogin activator (r-TPA; Actilyse), is safe, effective and achieves significantly better short and long term clinical outcome for patients.