Abstract
Atrial fibrillation (AF) and heart failure (HF) are epidemic cardiac diseases and are often detected in the same patient. Recent evidence suggests that this is not a mere coincidence but that the strategy of AF treatment may impact HF development. This review comprehensively summarizes current trial data on rhythm and rate control strategies in atrial fibrillation with a special focus on catheter ablation of AF in HF patients. For a long time, rate and rhythm control strategies for AF have been regarded as equal regarding long term mortality. Decision making has been based on the symptoms of patients. Current trials, however, show that the treatment strategy of AF and its effectiveness may significantly impact survival of HF patients. The benefits of rhythm control in HF patients may have been masked by side effects of antiarrhythmic drugs. If rhythm control, however, is achieved by catheter ablation, a reduction of HF related mortality can be observed. As catheter ablation of AF may reduce mortality in HF patients, AF ablation should be preferred over medical treatment in HF patients. In general, HF patients may profit most from rigorous AF treatment.
Highlights
Atrial fibrillation (AF) and heart failure (HF) are epidemic cardiac diseases and are often detected in the same patient
This review comprehensively summarizes current trial data on rhythm and rate control strategies in atrial fibrillation with a special focus on catheter ablation of AF in HF patients
Amiodarone therapy, the Antiarrhythmic drugs (AAD) most often used in patients with heart failure with reduced ejection fraction (HFrEF), has been associated with considerable discontinuation rates due to severe side effects and higher rates of noncardiovascular death.[24,28,29]. Corroborating this hypothesis, regression analyses from the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Study showed an association between sinus rhythm (SR) maintenance and mortality risk reduction, while antiarrhythmic therapy was associated with a high mortality rate.[30]
Summary
Atrial fibrillation (AF) and heart failure (HF) are epidemic cardiac diseases and are often detected in the same patient. Another large multicenter randomized trial published in 2008 (Atrial Fibrillation and Congestive Heart Failure trial, AF-CHF)[26] compared mortality between rhythm and rate control treatment strategies in 1376 AF patients with left ventricular ejection fraction (LVEF)
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