Abstract
Cathelicidin LL37: Defense Roles in the Early Stages of Mycobacterium Tuberculosis Infection
Highlights
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is the most deadly infectious diseases
Cathelicidin LL37 plays a vital role in innate immune response and can resist the invasion of MTB
The LL37/DNA complex produced by the Neutrophil Extracellular Traps (NETs) enters human peripheral blood mononuclear macrophages via the P2RX7 receptor and clathrin-mediated endocytosis, followed by Bactericidal action of Bacillus Calmette-Guerin (BCG) by lysosomes [9]
Summary
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is the most deadly infectious diseases. Cathelicidin LL37 plays a vital role in innate immune response and can resist the invasion of MTB. This article focuses on the role of cathelicidin LL37 in against MTB infection in vivo. MTB first triggers the innate immune response during infection and is phagocytosed by macrophages and dendritic cells, and is degraded into immunogenic polypeptides and presented on T lymphocytes by major histocompatibility complexes to trigger adaptive immunity [2].
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